Důkazem vysokého vzdělání je schopnost mluvit o největších věcech nejjednodušším způsobem.

David Hume

Literatura

Podívejte se do MedChemComm

MedChemComm is a multi-disciplinary journal which publishes both highly-significant research in traditional areas of medicinal chemistry and cutting edge work in new or interdisciplinary areas. The journal's mission is to broaden the field of opportunity for medicinal chemists, bringing new thinking to the subject and challenging perceptions of what is possible in drug discovery. Research in other disciplines which has an impact or application in medicinal chemistry is particularly welcomed and encouraged.
Co-Editors-in-Chief
Dr Anthony Wood, Pfizer, USA
Professor Greg Verdine, Harvard University, USA
Scope
MedChemComm welcomes highly significant research and review articles in medicinal chemistry, drug discovery, pharmacology and pharmaceutical research, including research which interfaces with other areas of the chemical sciences, biology, materials science or physics.
Examples of areas included within the journal's scope are:
• Chemical biology studies that enable drug discovery
• Novel technologies in areas such as biomaterials and nanotechnology that have potential application in drug discovery,
• Modifications of known chemical or biochemical entities that significantly improve pharmacological properties
• Design, synthesis and biological evaluation of novel chemical or biochemical entities which exhibit significant potential as new pharmacological agents, probes and/or potential drugs
• Computational, biophysical, physicochemical, molecular biological, proteomic studies of chemical or biochemical entities and their interaction within their biological environment
• Pharmacokinetic behaviour, pharmacodynamics, and drug safety and toxicology

Article Types
Concise Article: For the presentation of new results. Generally between 3 and 7 journal pages in length. Review: Critical reviews of key areas of medicinal chemistry research.

Emerging classes of armed antibody therapeutics against cancer

Christian Hess, Dario Venetz and Dario Neri
Med. Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3MD00360D, Review Article
First published online : 07 Jan 2014

There is a trend in oncology towards the development of ‘armed’ antibody products. In this article, some of the most advanced preclinical and clinical activities in the field of armed antibodies are reviewed.

Magazín Leonardo

Během transplantací implantátů orgánů hrozí vysoké riziko vzniku bakteriální infekce způsobené kontaminací z okolního prostředí. Bylo zjištěno, že jejich účinnost, především u stříbra, roste při vzniku komplexů nanočástic kovů s polymerními látkami jako je chitosan a kyselina hyaluronová. Inhibice replikace, strukturální změny buněčné stěny a intracelulárních a jaderných membrán, denaturace DNA a RNA jsou pozorovatelné i při působení nízkých koncentrací nanočástic stříbra. Escherichia coli O157: H7 a methicilin-rezistentní Staphylococcus aureus (MRSA) i při nízkých koncentracích SPNPs.
http://prehravac.rozhlas.cz/audio/3037025

All Databeses Web of Knowledge

Prima ZOOM

http://zoom.iprima.cz/clanky/top-10-nejlepsi-animovane-fotky-z-vedy-za-rok-2013

Novinky z knihovny

Je otevřen přístup do database časopisů ACS z MENDELU přístupového bodu. Využijte tyto přístupy maximální míře. http://pubs.acs.org/

Current Protocols

V rámci řešení projektu MENDELU RESEARCH LIBRARY http://mereli.mendelu.cz/ byl na webových stránkách http://www.mendelu.cz/cz/sluzby_sz/icuk/databaze zpřístupněn nový elektronický informační zdroj a to Wiley Current Protocols
http://onlinelibrary.wiley.com/browse/publications?type=labprotocols. Jedná se o trvalý nákup Current Protocols publikovaných 2013-2017.

Byla prodloužena platnost Seznamu recenzovaných neimpaktovaných periodik ČR o jeden rok, tj. do 31. 12. 2013. V hodnocení pro rok 2013 budou bodovány výsledky typu Jrec dle oborů stanovených v platné Metodice pro léta 2013 až 2015.

Metalothionein information servis (08 T)

Metallothionein - Immunohistochemical Cancer Biomarker: A Meta-Analysis
By: Gumulec, Jaromir; Raudenska, Martina; Adam, Vojtech; et al.
PLOS ONE Volume: 9 Issue: 1 Article Number: e85346 Published: JAN 8 2014

Enhanced Pb2+ biosorption by recombinant Saccharomyces cerevisiae expressing human metallothionein
By: Li, Min; Zhang, Zhibin; Shang, Jie; et al.
Conference: 2nd International Congress on Advanced Materials (ICAM) Location: Jiangsu Univ, Zhejiang, PEOPLES R CHINA Date: MAY 16-19, 2013
MONATSHEFTE FUR CHEMIE Volume: 145 Issue: 1 Pages: 235-240 Published: JAN 2014

Solution Structure of the Circular gamma-Domain Analog from the Wheat Metallothionein E-c-1
By: Tarasava, Katsiaryna; Johannsen, Silke; Freisinger, Eva
MOLECULES Volume: 18 Issue: 11 Pages: 14414-14429 Published: NOV 2013

Influenza (08 T)

New Small Molecule Entry Inhibitors Targeting Hemagglutinin-Mediated Influenza A Virus Fusion
By: Basu, Arnab; Antanasijevic, Aleksandar; Wang, Minxiu; et al.
JOURNAL OF VIROLOGY Volume: 88 Issue: 3 Pages: 1447-1460 Published: FEB 2014

Novel H7N9 Influenza Virus Shows Low Infectious Dose, High Growth Rate, and Efficient Contact Transmission in the Guinea Pig Model
By: Gabbard, Jon D.; Dlugolenski, Daniel; Van Riel, Debby; et al.
JOURNAL OF VIROLOGY Volume: 88 Issue: 3 Pages: 1502-1512 Published: FEB 2014

Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8(+) T Cells
By: Rutigliano, John A.; Sharma, Shalini; Morris, Melissa Y.; et al.
JOURNAL OF VIROLOGY Volume: 88 Issue: 3 Pages: 1636-1651 Published: FEB 2014

Impact of Potential Permissive Neuraminidase Mutations on Viral Fitness of the H275Y Oseltamivir-Resistant Influenza A(H1N1)pdm09 Virus In Vitro, in Mice and in Ferrets
By: Abed, Yacine; Pizzorno, Andres; Bouhy, Xavier; et al.
JOURNAL OF VIROLOGY Volume: 88 Issue: 3 Pages: 1652-1658 Published: FEB 2014

Accurate classification and hemagglutinin amino acid signatures for influenza A virus host-origin association and subtyping
By: ElHefnawi, Mahmoud; Sherif, Fayroz E.
VIROLOGY Volume: 449 Pages: 328-338 Published: JAN 20 2014

Evolution of Influenza Neuraminidase and the Detection of Antiviral Resistant Strains Using Mass Trees
By: Swaminathan, Kavya; Downard, Kevin M.
ANALYTICAL CHEMISTRY Volume: 86 Issue: 1 Special Issue: SI Pages: 629-637 Published: JAN 7 2014

information servis (06 T)

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