Důkazem vysokého vzdělání je schopnost mluvit o největších věcech nejjednodušším způsobem.

David Hume

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Nature Medicine is a biomedical research journal devoted to publishing the latest and most exciting advances in biomedical research for scientists and physicians, with an emphasis on clarity of presentation. Articles cover fields such as cancer biology, cardiovascular research, gene therapy, immunology, vaccine development, and neuroscience, aiming to keep Ph.D. and M.D. readers informed of a wide range of biomedical research findings. Original research articles published in Nature Medicine range from basic findings that have clear implications for disease pathogenesis and therapy to the earliest phases of human investigation, and are submitted from research groups at universities, independent research institutions, and biotechnology and pharmaceutical industries world-wide. As a cross-disciplinary journal at the heart of the international biomedical research community, Nature Medicine publishes the most relevant original research articles, news, and commentary that form the foundations of tomorrow's medicine. It begins as a slowly expanding spot of light or similar visual disturbance, often accompanied by phantom noises and other sensory distortions. People who experience such 'auras' know all too well that these early warning signs will culminate in a head-splitting migraine, yet scientists have little idea what causes the debilitating deluge of symptoms. Elie Dolgin talks to neurologists hoping to change that—by triggering auras in the laboratory in order to study them. Tobias Starmose was an avid runner. As a teenager, he competed in track competitions, winning several medals in the individual and relay sprinting events at the national youth championships in his native Denmark. But debilitating migraine headaches sidelined his athletic career. During practice, or more often on his way home afterward, a tiny bright spot would appear on one side of his vision. It would grow across his field of view and fill with wavy lines—like “heat waves,” Starmose says. His aura had begun. Pounding waves of pain in his head soon followed. The 22-year-old now avoids all strenuous exercise. He doesn't run anymore. He never showers after he wakes up (the hot water is a reliable stimulus, but only in the morning) and he makes sure to wear sunglasses whenever a cloud-filled sky beams down a certain hue of bluish-yellow light. “It's a constant regulation of what I know I can do and what my body is telling me I can do so I don't get any migraines,” Starmose says. By carefully limiting his exposure to potential trigger factors, Starmose figures that he now suffers only around one migraine, complete with a preceding aura, each month. But on a couple of occasions in 2011, he forwent his usual strategy of tactically avoiding problematic stimuli. Under the watch of neurologists, Starmose instead actively tried to set off the experience of aura. He ran up stairs at full tilt. He rode an exercise bicycle while wearing heavy rain gear, at times with a strobe light flashing in his face—all in the name of science. Starmose, who, inspired in part by this experience as a research subject, is now studying to be a doctor at Aarhus University in Denmark, was one of 27 participants of a clinical trial at the Danish Headache Center (DHC), located at the Glostrup Hospital on the outskirts of Copenhagen, which sought to determine a reliable and reproducible way to invoke aura attacks in the laboratory.

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Metalothionein information servis (35 T)

Title: Metallothionein 3: An androgen-upregulated gene enhances cell invasion and tumorigenesis of prostate carcinoma cells
Author(s): Juang, Horng-Heng; Chung, Li-Chuan; Sung, Hsin-Ching; et al.
Source: PROSTATE Volume: 73 Issue: 14 Pages: 1495-1506 Published: OCT 2013

Title: The polymorphism in the promoter region of metallothionein 1 is associated with heat tolerance of scallop Argopecten irradians
Author(s): Yang, Chuanyan; Wang, Lingling; Jiang, Qiufen; et al.
Source: GENE Volume: 526 Issue: 2 Pages: 429-436 Published: SEP 10 2013

Title: The Analysis of Metallothionein Immunoreactivity in Stromal Fibroblasts and Macrophages in Cases of Uterine Cervical Carcinoma With Respect to Both the Local and Distant Spread of the Disease
Author(s): Walentowicz-Sadlecka, Malgorzata; Koper, Anna; Krystyna, Galazka; et al.
Source: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY Volume: 70 Issue: 3 Pages: 253-261 DOI: 10.1111/aji.12120 Published: SEP 2013

Title: Bioavailability of purified subcellular metals to a marine fish
Author(s): Guo, Feng; Yao, Jie; Wang, Wen-Xiong
Source: ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY Volume: 32 Issue: 9 Pages: 2109-2116 DOI: 10.1002/etc.2286 Published: SEP 2013

Title: Competition of zinc(II) with cadmium(II) or mercury(II) in binding to a 12-mer peptide
Author(s): Jancso, Attila; Gyurcsik, Bela; Mesterhazy, Edit; et al.
Source: JOURNAL OF INORGANIC BIOCHEMISTRY Volume: 126 Pages: 96-103 DOI: 10.1016/j.jinorgbio.2013.05.019 Published: SEP 2013

Title: Degradation of aqueous synthesized CdTe/ZnS quantum dots in mice: differential blood kinetics and biodistribution of cadmium and tellurium
Author(s): Liu, Na; Mu, Ying; Chen, Yi; et al.
Source: PARTICLE AND FIBRE TOXICOLOGY Volume: 10 Pages: 37-37 Published: AUG 6 2013

Title: TSH induces metallothionein 1 in thyrocytes via G(q/11)- and PKC-dependent signaling
Author(s): Baeck, Christer M.; Stohr, Stefanie; Schaefer, Eva A. M.; et al.
Source: JOURNAL OF MOLECULAR ENDOCRINOLOGY Volume: 51 Issue: 1 Pages: 79-90 DOI: 10.1530/JME-12-0200 Published: AUG 2013

Title: Evolution of metallotionein isoforms complexes in hepatic cells of Mus musculus along cadmium exposure
Author(s): Jara-Biedma, R.; Gonzalez-Dominguez, R.; Garcia-Barrera, T.; et al.
Conference: 8th International Symposium Biometals Location: Brussels, BELGIUM Date: 2012
Source: BIOMETALS Volume: 26 Issue: 4 Pages: 639-650 DOI: 10.1007/s10534-013-9636-0 Published: AUG 2013

Title: Expression and functional role of metallothioneins I and II in the spinal cord in inflammatory and neuropathic pain models
Author(s): Kwon, Aram; Jeon, Sang-Min; Hwang, Sung-Hun; et al.
Source: BRAIN RESEARCH Volume: 1523 Pages: 37-48 DOI: 10.1016/j.brainres.2013.05.037 Published: JUL 26 2013

Title: Nanosized zinc oxide induces toxicity in human lung cells.
Author(s): Sahu, Devashri; Kannan, G M; Vijayaraghavan, R; et al.
Source: ISRN toxicology Volume: 2013 Pages: 316075 DOI: 10.1155/2013/316075 Published: 2013 Aug 07

Title: Immunohistochemical expression of metallothionein in pleomorphic adenoma of minor salivary glands: A role in the control of apoptosis?
Author(s): Miranda Viana, Alessandra de Castro; Ribeiro, Daniela Cotta; Guedes Florencio, Taynara Nunes; et al.
Source: ACTA HISTOCHEMICA Volume: 115 Issue: 6 Pages: 564-568 DOI: 10.1016/j.acthis.2012.12.004 Published: 2013

Title: Increased Metallothionein I/II Expression in Patients with Temporal Lobe Epilepsy
Author(s): Peixoto-Santos, Jose Eduardo; Galvis-Alonso, Orfa Yineth; Velasco, Tonicarlo Rodrigues; et al.
Source: PLOS ONE Volume: 7 Issue: 9 Article Number: e44709 DOI: 10.1371/journal.pone.0044709 Published: SEP 18 2012

Influenza (35 T)

Title: Using Amino Acid Factor Scores to Predict Avian-to-Human Transmission of Avian Influenza Viruses: A Machine Learning Study
Author(s): Wang, Jia; Kou, Zheng; Duan, Mojie; et al.
Source: PROTEIN AND PEPTIDE LETTERS Volume: 20 Issue: 10 Pages: 1115-1121 Published: OCT 2013

Title: Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis
Author(s): Miller, Matthew S.; Gardner, Thomas J.; Krammer, Florian; et al.
Source: SCIENCE TRANSLATIONAL MEDICINE Volume: 5 Issue: 198 Article Number: 198ra107 DOI:

Title: HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infection
Author(s): Hertz, Tomer; Oshansky, Christine M.; Roddam, Philippa L.; et al.
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Volume: 110 Issue: 33 Pages: 13492-13497 DOI: 10.1073/pnas.1221555110 Published: AUG 13 2013

Title: AVIAN INFLUENZA Critics Skeptical as Flu Scientists Argue for Controversial H7N9 Studies
Author(s): Malakoff, David
Source: SCIENCE Volume: 341 Issue: 6146 Pages: 601-601 Published: AUG 9 2013

Title: The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus
Author(s): Xu, Lili; Bao, Linlin; Deng, Wei; et al.
Source: VIROLOGY JOURNAL Volume: 10 Article Number: 253 DOI: 10.1186/1743-422X-10-253 Published: AUG 8 2013

Title: Design of inhibitors of influenza virus membrane fusion: Synthesis, structure-activity relationship and in vitro antiviral activity of a novel indole series
Author(s): Brancato, Virginia; Peduto, Antonella; Wharton, Stephen; et al.
Source: ANTIVIRAL RESEARCH Volume: 99 Issue: 2 Pages: 125-135 DOI: 10.1016/j.antiviral.2013.05.005

Title: Human 4F5 single-chain Fv antibody recognizing a conserved HA1 epitope has broad neutralizing potency against H5N1 influenza A viruses of different clades
Author(s): Zhang, Xiao; Qi, Xian; Zhang, Qianqian; et al.
Source: ANTIVIRAL RESEARCH Volume: 99 Issue: 2 Pages: 91-99 DOI: 10.1016/j.antiviral.2013.05.001 Published: AUG 2013

Title: The lung microvascular endothelium as a therapeutic target in severe influenza
Author(s): Armstrong, Susan M.; Mubareka, Samira; Lee, Warren L.
Source: ANTIVIRAL RESEARCH Volume: 99 Issue: 2 Pages: 113-118 DOI: 10.1016/j.antiviral.2013.05.003

Title: Application of three duplex real-time PCR assays for simultaneous detection of human seasonal and avian influenza viruses
Author(s): Stefanska, Ilona; Dzieciatkowski, Tomasz; Brydak, Lidia B.; et al.
Source: ARCHIVES OF VIROLOGY Volume: 158 Issue: 8 Pages: 1743-1753 DOI: 10.1007/s00705-013-1648-0 Published: AUG 2013

Title: Subsisting H1N1 influenza memory responses are insufficient to protect from pandemic H1N1 influenza challenge in C57BL/6 mice
Author(s): Sage, Leo K.; Fox, Julie M.; Tompkins, Stephen M.; et al.
Source: JOURNAL OF GENERAL VIROLOGY Volume: 94 Pages: 1701-1711 DOI: 10.1099/vir.0.049494-0 Part: 8 Published: AUG 2013

Title: Comparative Glycomics Analysis of Influenza Hemagglutinin (H5N1) Produced in Vaccine Relevant Cell Platforms
Author(s): An, Yanming; Rininger, Joseph A.; Jarvis, Donald L.; et al.
Source: JOURNAL OF PROTEOME RESEARCH Volume: 12 Issue: 8 Pages: 3707-3720 DOI: 10.1021/pr400329k Published: AUG 2013

Title: INFLUENZA VIRUS Lethal weapons
Author(s): Leavy, Olive
Source: NATURE REVIEWS IMMUNOLOGY Volume: 13 Issue: 8 Pages: 543-543 DOI: 10.1038/nri3502 Published: AUG 2013

Title: Influenza A (H7N9) and the Importance of Digital Epidemiology
Author(s): Salathe, Marcel; Freifeld, Clark C.; Mekaru, Sumiko R.; et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 369 Issue: 5 Pages: 401-404 DOI:

Title: Influenza Virus M2e with Additional Cysteine Residues Shows Enhanced Immunogenicity and Protection Against Lethal Virus Challenge
Author(s): Kaminaka, Kazuyoshi; Matsuda, Jun-ichi; Nozaki, Chikateru
Source: VIRAL IMMUNOLOGY Volume: 26 Issue: 4 Pages: 291-295 DOI: 10.1089/vim.2013.0001 Published: AUG

Title: Evaluation of Mucosal and Systemic Immune Responses Elicited by GPI-0100-Adjuvanted Influenza Vaccine Delivered by Different Immunization Strategies
Author(s): Liu, Heng; Patil, Harshad P.; de Vries-Idema, Jacqueline; et al.
Source: PLOS ONE Volume: 8 Issue: 7 Article Number: UNSP e69649 DOI: 10.1371/journal.pone.0069649

Title: High-Resolution Temporal Response Patterns to Influenza Vaccine Reveal a Distinct Human Plasma Cell Gene Signature
Author(s): Henn, Alicia D.; Wu, Shuang; Qiu, Xing; et al.
Source: SCIENTIFIC REPORTS Volume: 3 Article Number: 2327 DOI: 10.1038/srep02327 Published: JUL 31 2013

Title: Immunogenicity, reactogenicity and safety of an inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine: a phase III, randomized trial in adults aged >= 18 years
Author(s): Kieninger, Dorothee; Sheldon, Eric; Lin, Wen-Yuan; et al.
Source: BMC INFECTIOUS DISEASES Volume: 13 Article Number: 343 DOI: 10.1186/1471-2334-13-343 Published: JUL 24 2013

Title: Comparison of Different Risk Perception Measures in Predicting Seasonal Influenza Vaccination among Healthy Chinese Adults in Hong Kong: A Prospective Longitudinal Study
Author(s): Liao, Qiuyan; Wong, Wing Sze; Fielding, Richard
Source: PLOS ONE Volume: 8 Issue: 7 Article Number: e68019 DOI: 10.1371/journal.pone.0068019 Published: JUL 19 2013

Title: High-Content Analysis of Sequential Events during the Early Phase of Influenza A Virus Infection
Author(s): Banerjee, Indranil; Yamauchi, Yohei; Helenius, Ari; et al.
Source: PLOS ONE Volume: 8 Issue: 7 Article Number: e68450 DOI: 10.1371/journal.pone.0068450 Published: JUL 12 2013

Title: Model-Based Simulation and Prediction of an Antiviral Strategy against Influenza A Infection
Author(s): Hur, Kye-Yeon; Moon, Joon-Young; Kim, Seung-Hwan; et al.
Source: PLOS ONE Volume: 8 Issue: 7 Article Number: e68235 DOI: 10.1371/journal.pone.0068235 Published: JUL 9 2013

Title: Excessive Cytokine Response to Rapid Proliferation of Highly Pathogenic Avian Influenza Viruses Leads to Fatal Systemic Capillary Leakage in Chickens
Author(s): Kuribayashi, Saya; Sakoda, Yoshihiro; Kawasaki, Takeshi; et al.
Source: PLOS ONE Volume: 8 Issue: 7 Article Number: e68375 DOI: 10.1371/journal.pone.0068375 Published: JUL 9 2013

Title: Intrinsic TNF/TNFR2 Interactions Fine-Tune the CD8 T Cell Response to Respiratory Influenza Virus Infection in Mice
Author(s): Wortzman, Michael E.; Lin, Gloria H. Y.; Watts, Tania H.
Source: PLOS ONE Volume: 8 Issue: 7 Article Number: UNSP e68911 DOI: 10.1371/journal.pone.0068911 Published: JUL 9 2013

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