Detection of sentinel lymph node using magnetic nanoparticles

There was developed further application of nanotechnology- detection of sentinel lymph node by magnetic nanoparticles. Sentinel lymph node biopsy is the standard surgical procedure for the axilla in early node-negative breast cancer. If no cancer is detected in the sentinel lymph node, there is no need for an axillary lymph node dissection in which usually 30 or so lymph nodes are removed. Axillary node dissection is often complicated by arm lymphedema. Moreover sentinel lymph node biopsy procedure results in shorter breast cancer operations and better patient recovery compared to node dissection.

1. Douek M, Klaase J, Monypenny I, Kothari A, Zechmeister K, Brown D, Wyld L, Drew P, Garmo H, Agbaje O, Pankhurst Q, Anninga B, Grootendorst M, Ten Haken B, Hall-Craggs MA, Purushotham A, Pinder S; SentiMAG Trialists Group.Sentinel node biopsy using a magnetic tracer versus standard technique: the SentiMAG Multicentre Trial. Ann Surg Oncol. 2014;21(4):1237-45
2.  ill M, Kurylcio A, Welter R, van Haasteren V, Grosse B, Berclaz G, Polkowski W, Hauser N.  e Central-European SentiMag study: sentinel lymph node biopsy with superparamagnetic iron oxide (SPIO) vs. radioisotope. Breast. 2014;23(2):175-9

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