Application of quantum dots into chicken embryos

Quantum dots (QDs) are small semiconductor nanoparticles with great optical properties. Their behaviour enables the usage of QDs in in vitro and in vivo experiments and they are promising tools in disease treatment and targeted therapy. The limitation of their usage is the toxicity. Quantum dots consist of different metals, which have various effects on the health. To decrease their toxicity, different surface coatings are used. The effect of QDs on the organism can be tested on chicken embryos. Chicken embryos represent great model for QDs toxicity studies, because there is no need of any permission for the work with embryos and the experiments are low cost and fast.

Fig.1: Different CdTe QDs applied into the chicken embryo (18th developmental day) detected by In vivo Xtreme by Carestream (Rochester, NY, USA). The fluorescence of three different QDs detected with excitation filter: 480 nm and emission filter: 535 nm (CdTe green), 600 nm (CdTe yellow) and 700 nm (CdTe red). The fluorescence images were overlayed with x-ray image.

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