Protease inhibitor
The most important are tripsin and chymotripsin inhibitors in animal nutrition. They are polypeptides and proteins creating quite persistent complexes with proteolytic enzymes, which have lower enzymatic activity. Faba bean seeds have even two times higher content of protease inhibitors in seed coat than in cotyledons. Protease inhibitors have these physiologic effects (KALAČ a MÍKA, 1997):
- inhibit growth intensity
- restrict protein fissure and their digestibility in poultry, but only a little in gnawers
- induce pancreas hypertrophy and hyperplasia and higher trypsin and chymotripsin synthesis (requirement of methionine and cysteine increase)
- cause endogenous waste of nitrogen and sulfur
- stimulate production matters which support pancreatic enzymes secretion
- adult animals are less sensitive to protease inhibitors
- etc.
Possibilities of protease inhibitors neggative effects restriction (KALAČ and MÍKA, 1997):
- breeding and genetic engineering of leguminous (pursuit to obtain heat-labile varieties
- heat treatment with occasion to add alcaline silicates
- extrusion.
Created by: Ivo